Clinical Studies of HIV and Aids

(There are clinical studies topically related to our research here. We prefer to base our nutritional products on clinical studies more than testimonies. Some studies are listed at the end of particular articles. More can be found under the general topics of Monolaurin, Lactoferrin, Essential Oils, etc.)

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Bergsson G, Steingrímsson Ó, Thormar H. In vitro susceptibilities of Neisseria gonorrhoeae to fatty acids and monoglycerides. Antimicrob Agents Chemother. 1999;43:2790–2792.

Chang, Louise MD. 2009 Reviewed by; March New Vaginal Gel Stops AIDS Virus. Cosmetic Ingredient glycerol monolaurate (GML) protects monkeys from AIDs Virus. WebMD Health News

Craig, G.B., et al. Decreased fat and nitrogen losses in patients with AIDS receiving medium-chain-triglyceride-enriched formula vs those receiving long-chain-triglyceride-containing formula. J Am Diet Assoc 1997;97:605-611.

Dayrit, CS. 2000. Coconut oil in health and disease: its, and monolaurin’s potential as cure for HIV/AIDS. Presented at the 37th Cocotech Meeting/ICC, July 25, 2000. Chennai, India. pp. 110-122.

Enig, MG. Lauric oils as antimicrobial agents: theory of effect, scientific rationale, and dietary applications as adjunct nutritional support for HIV-infected individuals. in Nutrients and Foods in AIDS (RR Watson, ed) CRC Press, Boca Raton, 1998, pp. 81-97.

Enig, MG HIV-infected individuals in Nutrients and Foods in AIDS (RR Watson, ed) CRC Press, Boca Raton, 1998, pp. 81-97.

Fichorova, R. N., P. J. Desai, F. C. Gibson III, and C. A. Genco. 2001. Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cells. Infect. Immun.69:5840–5848.

Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro. Sex Transm Infect. 1999 June; 75(3): 181-185.

Neyts, J., et al. Hydrogels containing monocaprin prevent intravaginal and intracutaneous infections with HSV-2 in mice: impact on the search for vaginal microbicides. J Med Virol 2000;61(1):107-110.

Tayag E, Dayrit CS. Results analysis of clinical HIV trial with monoglycerides [presentation]. The 37th Cocotech Meeting, Chennai, India, July 25, 2000.

Thormar, H., Bergsson, G., Gunnarsson, E., Georgsson, G., Witvrouw, M., Steingrímsson, Ó., De Clercq, E., and Kristmundsdóttir, Y. Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro. Sexually Transmitted Infections 75, 181-185, 1998.

Wanke, C.A., et al. A medium chain triglyceride-based diet in patients with HIV and chronic diarrhea reduces diarrhea and malabsorption: a prospective, controlled trial. Nutrition 1996;12:766-771.

Against Enveloped RNA and DNA Viruses (which includes HIV)

Hierholzer, J.C. and Kabara, J.J. In Vitro Effects of Monolaurin Compounds on Enveloped RNA and DNA Viruses. J. Of Food Safety 4:1-12 (1982)

Isaacs CE et al. (1994) Inactivation of enveloped viruses in human bodily fluids by purified lipids. Ann NY Acad Sci 724:457-464.

Isaacs CE and Schneidman K. (1991) Enveloped viruses in human and bovine milk are inactivated by added fatty acids(FAs) and monoglycerides(MGs). J FASEB 5: Abstract 5325, p.A1288.

Isaacs CE, Thormar H. Membrane-disruptive effect of human milk: inactivation of enveloped viruses. Journal of Infectious Diseases 1986; 154:966-971.

In vitro effects of monolaurin compounds on enveloped RNA and DNA viruses. Journal of Food Safety. 1982; 4: 1-12

Inactivation of Enveloped Viruses and killing of cells by Fatty Acids and Monoglycerides. Antimicrobial Agents and Chemotherapy. 1987 January; 31(1): 27-31

Sands, J, et al. Extreme sensitivity of enveloped viruses, including Herpes Simplex, to long chain unsaturated monoglycerides and alcohols, Antimicrobial Agents and Chemotherapy. 15; 1:67-73, 1979.

Thormar H et al. (1987) Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrobial Agents Chemother 31:27-31.

Thormar, H., C. E. Isaacs, K. S. Kim, and H. R. Brown. 1994. Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides. Ann. N. Y. Acad. Sci. 724:465–471.

Thormar H, Isaacs C E, Brown H R, Barshatzky M R, Pessolano T. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob Agents Chemother. 1987;31:27–31.

Other Studies:

Bergsson G, Amfinnsson J, Karlsson SN’rSteingrinisson 0, Thormar H. In vitro inactivation of Chlamydia trachomatis by fatty acids and monoglycerides. Antimicrobial Agents and Chemotherapy 1998;42:2290-2294

Glycerol monolaurate prevents mucosal SIV (simian immunodeficiency virus) transmission. Nature. 2009 April; 458: 1034-1038

Kabara, J.J. Antimicrobial agents derived from fatty acids. Journal of the American Oil Chemists Society 1984;61:397-403.

Laga, M., A. Manoka, M. Kivuvu, B. Malele, M. Tuliza, N. Nzila, J. Goeman, F. Behets, V. Batter, M. Alary, et al. 1993. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS 7:95–102.

Macallan D. C., Noble C., Baldwin C., Foskett M., McManus T., Griffin G. E. Prospective analysis of patterns of weight change in stage IV human immunodeficiency virus infection. Am. J. Clin. Nutr. 1993; 58:417-424.

Onderdonk, A. B., M. L. Delaney, G. R. Zamarchi, M. L. Hirsch, A. Munoz, and E. H. Kass. 1989. Normal vaginal microflora during use of various forms of catamenial protection. Rev. Infect. Dis. 11(Suppl. 1):S61– S67.90]

Plummer, F. A. 1998. Heterosexual transmission of human immunodeficiency virus type 1 (HIV): interactions of conventional sexually transmitted diseases, hormonal contraception and HIV-1. AIDS Res. Hum. Retrovir.14(Suppl. 1):S5–S10.

Radical Approach to Block HIV Gets Some Results. Dream Big Dreams, 2009 March

University of Minnesota discovery offers potential breakthrough in preventing HIV transmission. Minnesota Public Radio, 2009 March.