References: Fibrin and Biofilms

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Barthold SW, Hodzic E, Imai DM, Feng S, Yang X, et al. (2010) Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. Antimicrobial Agents & Chemotherapy 54: 643–651.

Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Bransa SS, Vik S, Friedman L, Kolter R (2005) Biofilm: the matrix revisited. Trends Microbiol 13: 20–26.

Brorson O, Brorson SH. An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to tinidazole. Int Microbiol. 2004 Jun;7(2):139-42.

Brorson O, Brorson SH. An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to hydroxychloroquine. Int Microbiol. 2002 Mar;5(1):25-31.

Brorson O, Brorson SH. Susceptibility of motile and cystic forms of Borrelia burgdorferi to ranitidine bismuth citrate. Int Microbiol. 2001 Dec;4(4):209-15.

Brorson O, Brorson SH. An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to metronidazole. APMIS. 1999 Jun;107(6):566-76.

Brorson O, Brorson SH. Transformation of cystic forms of Borrelia burgdorferi to normal, mobile spirochetes. Infection 1997; 25(4):240]6.

Brorson O, Brorson SH. In vitro conversion of Borrelia burgdorferi to cystic forms in spinal fluid, and transformation to mobile spirochetes by incubation in BSK]H medium. Infection 1998; 26(3):144]50.

Brorson O, Brorson SH. A rapid method for generating cystic forms of Borrelia burgdorferi, and their reversal to mobile spirochetes. APMIS 1998; 106(12):1131]41.

Burgdorfer W, Hayes SF. Vector spirochete relationship in louse]borne and tickborne borreliosis with emphasis on Lyme disease. In Advances of Disease Vector Research, pp. 127±150. Edited by K. F. Harris. New York: Springer. 1989

Costerton JW, Stewart PS, Greenburg EP (1999) Bacterial biofilms, a common cause of persistent infections. Science 284: 1318–1322. doi: 10.1126/science.284.5418.1318.

Donlan RM, Costerton WJ (2002) Biofilms: Survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 15: 167–193. doi: 10.1128/CMR.15.2.167-193.2002.

Donta ST. Macrolide therapy of chronic Lyme Disease. Med Sci Monit. 2003 Nov;9(11):PI136-42.

Gruntar I, Malovrh T, Murgia R, Cinco M. Conversion of Borrelia garinii cystic forms to motile spirochetes in vivo. APMIS 2001; 109(5):383]8.

Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis. Eur Heart J. 2003;24:499-500.

Esch PM, et al Reduction of postoperative swelling objective measurement of the upper ankle joint in treatment with serrapeptase ——- A prospective study (German); Fortschr Med. 1989; 107(4)67-8, 71-2

Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391.

Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain. 2001;124(Pt 10):1978-1988.

Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet. 1987;2:3-9.

Hodzic E, Feng S, Holden K, Freet KJ, Barthold SW (2008) Persistence of Borrelia burgdorferi following antibiotic treatment in mice. Antimicrob Agents Chemother 52: 1728–1736.

Hoyle BD, Costerton JW (1991) Bacterial resistance to antibiotics: the role of biofilms. Prog Drug Res 37: 91–105.

Kee WH, et al. The treatment of breast engorgement with serrapeptase (Danzen) a randomized double-blind controlled trial. Singapore MJ 1989; 48-54

Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196.

Kersten A, Poitscheck S, Rauch S, Aberer E. Effects of penicillin, ceftriaxone, and doxycycline on morphology of Borrelia burgdorferi. Antimicrob Agents Chemother 1995; 39:1127]33.

Kurtti TG, Munderloh UG, Johnson RC, Ahlstrand GG (1987) Colony formation and morphology in Borrelia burgdorferi. J Clin Microbiol 25: 2054–2058.

Liegner KB, Shapiro JR, Ramsey D, Halperin AJ, Hogrefe W, et al. (1993) Recurrent erythemamigrans despite extended antibiotic treatment with minocycline in a patient with persisting Borrelia burgdorferi infection. J American Acad Dermatol 28: 312–314.

Logigian EL, Kaplan RF, Steere AC. Chronic neurologic manifestations of Lyme disease. N Engl J Med 1990;323:1438]44.

MacDonald AB. Concurrent neocortical borreliosis and Alzheimer’s disease: Demonstration of a spirochetal cyst form. Ann NY Acad Sci 1988; 539:468]70.

Mazzone A. et al. Evaluation of serratia peptidase in acute or chronic inflammation of otolaryngology pathology: A multi-centre, double-blind, randomized trial versus placebo. Journal of International Medical Research 1990, 379-88

Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15.

Meletis CD, Barker JE. Therapeutic enzymes: using the body’s helpers as healers. Alt Comp Ther. 2005;74-77.

Miklossy J, Kasas S, Zurn AD, McCall S, Yu S, McGeer PL. Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J Neuroinflammation 2008; 25;5:40.

Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164.

Murgia R, Piazzetta C, Cinco M. Cystic forms of Borrelia burgdorferi sensu lato: induction, development, and the role of RpoS. Wien Klin Wochenschr 2002; 114(13]14):574]9.

Murgia R, Cinco M. Induction of cystic forms by different stress conditions in Borrelia burgdorferi. APMIS. 2004; 112(1):57]62.

Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645.

Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142.

Panaguriya A., et al. A preliminary trial of serrapeptase in patients with carpal tunnel syndrome. J Assoc Physician India; 47(12):170-172

Preac-Mursic V, Weber K, Pfister HW, Wilske B, Gross B, Baumann A., et al. (1989) Survival of Borrelia burgdorferi in antibiotically treated patients with Lyme borreliosis. Infect 17: 335–339.

Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149.

Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305.

Sapi E, MacDonald A (2008) Biofilms of Borrelia burgdoferi in chronic cutaneous borreliosis. Am J Clin Pathol 129: 988–989.

Selan L., et al. Protolutic Enzymes: A new treatment strategy for prosthetic infections? Antimicro Agents Chemother, 1993;37(12):2618-21

Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168.

Stewart P, Costerton JW (2001) Antibiotic resistance of bacteria in biofilms. Lancet 358: 135–138. doi: 10.1016/S0140-6736(01)05321-1.

Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143.

Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987;43:1110-1111.

Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298.