Putting the Pieces Together

Putting the Pieces Together

Health

Questions?
Give us a call:
503-767-2400
Mon-Fri 8-4 PDT
  • Home – Disease Protocols
    • Lyme Disease
    • Mitochondria Energy
    • Coronavirus Defense
    • 3-Step Flu Defense
    • MRSA Staph
    • Mind & Memory
    • Artery Plaque
    • Cholesterol
    • Joint Health
    • Chronic Inflammation
    • Hepatitis
    • Herpes & Shingles
    • Fibromyalgia
    • Chronic Fatigue
    • HIV
    • Liver & Kidney
    • Scar Tissue & Cysts
  • A-Z Topics
    • A-Z List of Topics
    • About PPT Health
    • Contact Us
  • Protocol Supplements
    • #1: Monolaurin
    • #2: Biofilm Dissolving Enzymes
    • #3 The Mitochondria Energy Blend
    • #4: Mind and Memory Blend
    • #5: Heavy Metal Detox
    • #6: Inflammation Relief
    • #7: Foundation Multi-Nutrient
    • #8: Artery Plaque Reduction
    • #9: High Cholesterol Blend
    • #10: Joint Health
    • #11 Dia-Mazing
    • Skin Care Essentials
  • About Us
  • Blog
  • Contact Us
You are here: Home / AngioGenesis Articles / Dr. Li – 2. The Development and Prevention of Cancer

Dr. Li – 2. The Development and Prevention of Cancer


(This is part two of three articles with excerpts from
“Tumor Angiogenesis as a Target for Dietary Cancer Prevention”
by Dr. William Li.)


The Dormant-to-Tumor Phase of Cancer

   Cancer cells are common in a healthy adult but small tumor growth remains limited.(37-39)  Tumors can grow to about the size of a pin head before maxing out.  They can’t get enough oxygen and nutrients (by osmosis) from nearby blood vessels.  The rate of tumor cancer cell growth, therefore, is limited to the rate of cells dying.(40)

   These tumors are common, but limited, during aging.  Lack of new blood vessels (anti-angiogenesis) is regarded as one of the body’s mechanisms that prevent these cancer cells from converting to a malignant cancer.

   To expand, tumors recruit new blood vessels from surrounding vessels, an event known as ‘the switch’.(41)  New blood vessel growth is encouraged by the production of angiogenic growth factors by mutated cancer cells.

   Angiogenesis is clearly evident during this further growth. Distinct stages are observed from mild and aggressive fibromas to fibrosarcoma (secreting bFGF not secreted by normal cells or by mild fibromas).

   It is also significant that inflammatory cells may amplify the angiogenic switch!

   The onset of angiogenesis precedes an exponential phase of tumor growth.  Once new blood vessels reach the explant, tumors can expand 16,000-fold in size in 2 weeks.(42)

Targeting Tumor Angiogenesis for Cancer Prevention

   The concept of “anti-angiogenesis” was first proposed in 1971 by Judah Folkman.  He suggested that preventing new blood vessel growth at an early stage of cancer development could prevent tumor growth.(4)  Since then, many studies show angiogenesis inhibition (anti-angiogenesis) may be an effective strategy to restrict cancer growth in a wide variety of cancers.(5, 43)

   Selective targeting of angiogenic blood vessels is possible because normal blood vessel endothelial cells have a very slow doubling time.(44-46)  In contrast, tumor blood vessel cells can double in a few weeks.  Thus, anti-angiogenic molecules are geared to inhibiting tumor blood vessel growth – but do not affect normal blood vessels!

   Specific targets have been identified for tumor angiogenesis with drugs. However, it has been suggested that a synergy of different nutrients with the different active extracts may be a better broad prevention for supplementation to foods. To date, more than 300 anti-angiogenesis molecules have been identified as potential drug candidates, including many natural ones.

Early Intervention and Cancer Prevention

   Advanced cancers contain well-established, extensive vascular networks that may respond minimally to angiogenesis inhibitors. This is why intervention for cancer prevention or early-stage cancer has been proposed as the scenario of the greatest clinical benefit using angiogenesis inhibitors.(50)

   Anti-angiogenesis offers an opportunity to interrupt an early tumor growth.(51-52)  Suppression of blood-vessel growth prevents early tumors from progressing to the malignant phenotypes.

   Animal studies have demonstrated that early administration of angiogenesis inhibitors is highly effective.  In one study, treated tumors were reduced by 90%, compared to control animals. In another study tumor growth was suppressed in the TNP-470-treated group by 82%, compared to saline-treated controls.(40,53)

   “Cancer chemoprevention” is defined as the use of pharmacological, natural or dietary agents to inhibit the development of invasive cancer.  It does this by blocking DNA damage or by arresting the progression of premalignant cells after damage has already occurred.(54)

References
  1. C. Y. Li, S. Shan, Q. Huang et al., “Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models,” Journal of the National Cancer Institute, vol. 92, no. 2, pp. 143–147, 2000.
  1. J. Holash, P. C. Maisonpierre, D. Compton et al., “Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF,” Science, vol. 284, no. 5422, pp. 1994–1998, 1999. V
  1. J. Folkman, “Incipient angiogenesis,” Journal of the National Cancer Institute, vol. 92, no. 2, pp. 94–95, 2000.
  1. L. Holmgren, M. S. O’Reilly, and J. Folkman, “Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression,” Nature Medicine, vol. 1, no. 2, pp. 149–153, 1995.
  1. W. W. Li, “Tumor angiogenesis: molecular pathology, therapeutic targeting, and imaging,” Academic Radiology, vol. 7, no. 10, pp. 800–811, 2000.
  1. M. A. Gimbrone Jr., S. B. Leapman, R. S. Cotran, and J. Folkman, “Tumor dormancy in vivo by prevention of neovascularization,” Journal of Experimental Medicine, vol. 136, no. 2, pp. 261–276, 1972.
  1. J. Folkman, “Antiangiogenesis agents,” in Cancer Principles & Practice of Oncology, V. T. DeVita, S. Hellman, and S. A. Rosenberg, Eds., pp. 509–519, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 6th edition, 2001.
  1. R. L. Engerman, D. Pfaffenbach, and M. D. Davis, “Cell turnover of capillaries,” Laboratory Investigation, vol. 17, no. 6, pp. 738–743, 1967.
  1. B. Hobson and J. Denekamp, “Endothelial proliferation in tumours and normal tissues: continuous labelling studies,” British Journal of Cancer, vol. 49, no. 4, pp. 405–413, 1984.
  1. I. F. Tannock, “Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor,” Cancer Research, vol. 30, no. 10, pp. 2470–2476, 1970.
  1. S. A. Hill, G. M. Tozer, G. R. Pettit, and D. J. Chaplin, “Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503,” Anticancer Research, vol. 22, no. 3, pp. 1453–1458, 2002.
  1. H. Goto, S. Yano, H. Zhang et al., “Activity of a new vascular targeting agent, ZD6126, in pulmonary metastases by human lung adenocarcinoma in nude mice,” Cancer Research, vol. 62, no. 13, pp. 3711–3715, 2002.
  1. D. W. Siemann, E. Mercer, S. Lepler, and A. M. Rojiani, “Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy,” International Journal of Cancer, vol. 99, no. 1, pp. 1–6, 2002.
  1. W. W. Li, V. W. Li, R. Casey, et al., “Clinical trials of angiogenesis based therapies: overview and new guiding principles,” in Angiogenesis Models, Modulators and Clinical Application, M. Maragoudakis, Ed., pp. 475–492, Plenum Press, New York, NY, USA, 1998.
  1. N. B. Teo, B. S. Shoker, L. Martin, J. P. Sloane, and C. Holcombe, “Angiogenesis in pre-invasive cancers,” Anticancer Research, vol. 22, no. 4, pp. 2061–2072, 2002.
  1. P. Vajkoczy, M. Farhadi, A. Gaumann et al., “Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2,” Journal of Clinical Investigation, vol. 109, no. 6, pp. 777–785, 2002.
  1. S. Shusterman, S. A. Grupp, R. Barr, D. Carpentieri, H. Zhao, and J. M. Maris, “The angiogenesis inhibitor TNP-470 effectively inhibits human neuroblastoma xenograft growth, especially in the setting of subclinical disease,” Clinical Cancer Research, vol. 7, no. 4, pp. 977–984, 2001.
  1. Chemoprevention Working Group, “Prevention of cancer in the next millennium: report of the Chemoprevention Working Group to the American Association for Cancer Research,” Cancer Research, vol. 59, no. 19, pp. 4743–4758, 1999. View at Google Scholar • View at Scopus

What People Are Saying:

I’m a holistic health practitioner with over 30 years of experience. I’ve suffered from chronic fatigue syndrome and slowly worked up to 3 full scoops of Monolaurin a day and can’t believe the results…I haven’t felt this good in YEARS!

Marcie J. Inspired Nutrition Monolaurin

Read More Testimonials

Using the Monolaurin and Bio-Fibrin, I brought my viral load down 2 million with the first Jar.  

Leola A. Inspired Nutrition Bio-Fibrin

Read More Testimonials

Thanks to your protocol I on my way to ridding myself of Hepatitis C. after 20 years! My viral load was 10 million + and after 90 days of monolaurin, 3 scoops per day, it has dropped to under 2 million! 

Richard W. Inspired Nutrition Monolaurin

Read More Testimonials

Before taking Monolaurin, I would have herpes (simplex 1) outbreaks at least once every month. I took Monolaurin 2x a day for one month and have not had a single outbreak since!

Anonymous Inspired Nutrition Monolaurin

Read More Testimonials

After my diagnosis of HIV/AIDS 3 years ago, your products brought me to a degree of health I experienced as an athlete prior to my diagnosis. I am free of HIV through multiple tests and off all pharm. medicines.  

Kirk E. Inspired Nutrition Monolaurin

Read More Testimonials

I’ve been using Monolaurin for about 2 years now for Herpes and have not had one outbreak since taking it.  Every once in a while when I feel I may be close to an outbreak, I increase my dosage for a couple of days and it goes away.

Anonymous, CA Inspired Nutrition Monolaurin

Read More Testimonials

The Monolaurin has been a miracle for helping me with my shingles.  I am symptom-free after taking it for just a short time at three scoops a day. 

Susan F. Inspired Nutrition Monolaurin

Read More Testimonials

I am a 59 year-old woman and have had major outbreaks of genital herpes since I was 20. I started Monolaurin about 1½ year ago. The only outbreak I’ve had was when I was feeling so good I forgot to take it. Thank you for this wonderful supplement that has changed my life! 

Anonymous, OR Inspired Nutrition Monolaurin

Read More Testimonials

Nothing ever worked to rid my skin problem like Skin Defense. So I am ordering the 32oz bottle. 

G.L Ramona Inspired Nutrition Skin Defense

Read More Testimonials

I have Fibromyalgia and often can’t sleep at night due to pain. Since taking monolaurin before bed, I sleep deeper and with much less pain than in the past.  The relief is significant and lasts.

Eric T. Inspired Nutrition Monolaurin

Read More Testimonials

My wife had MRSA so bad that the Dr. said she was going to die. They could not even come close to killing it. She has had MS for 43 yrs but I didn't want MRSA to kill her. She started taking monolaurin &. Bio fibrin & within 2 weeks she was getting better along with cleaning up her UTI infection. She is alive today because of your product, thank you very much!!!

 

Tom K. Inspired Nutrition Bio Fibrin

Read More Testimonials

I have had Hepatitis C for 25 years and I started taking monolaurin three times a day and in six months my viral load went from 9,990,000 to 468,000, at this rate by my next blood test in six months the virus should be cleared and undetected. 

Anonymous Inspired Nutrition Monolaurin

Read More Testimonials

My brother told me how the doctors could not believe how our cousin’s wife recovered, when all of us relatives knew she was dying from battling MRSA. She took your products and was healed from it! I know this to be true because she was able to fly to visit family in the last couple of weeks!... No one in our family would ever think she could have done that as bad as she was before with MRSA. What a miracle!

Carolyn H. Inspired Nutrition Monolaurin

Read More Testimonials

My daughter and I start taking Monolaurin when we feel like we are getting a cold or sinus infection. We used to get them quite regularly but now we have not had one in 2 years. 

Anonymous, OH Inspired Nutrition Monolaurin

Read More Testimonials

I have been battling Chronic Lyme Disease and have been supplementing with Monolaurin. I believe this product has helped me cope with Lyme symptoms with no need to fear any bad side effects. 

Anonymous, PA Inspired Nutrition Monolaurin

Read More Testimonials

I am so grateful there is a product out there like Monolaurin that could help me get healthy in a safe way. Within a month of using Monolaurin, my energy level tripled, and as a result, I’m a much happier person.  

Anonymous, MA Inspired Nutrition Monolaurin

Read More Testimonials

I ordered the C-A-Y Defense cream and this stuff is incredible! It heals everything from my cuts and scratches to my psoriasis, I highly recommend it!

Roberta P. Inspired Nutrition C-A-Y Defense Cream

Read More Testimonials

Questions?

We've Got Answers!

See our FAQ

Sign-up Today!

To receive our health newsletter, including information related to:

  • Our disease protocols
  • Recommended nutrients and formulas
  • Living a healthy lifestyle, naturally

Note: We will not share your email address with any other party. If you wish to opt out of the newsletter distribution, you may unsubscribe at any time.

Follow PPT Health:

  • Facebook

The information provided by this website has not been evaluated by the Food and Drug Administration. Information and products are not intended to diagnose, treat, cure or prevent any disease. Persons taking pharmaceutical medications and those with medical conditions should consult with a healthcare professional before using any products. While we make extensive effort to provide accurate information and opinions from sources believed to be correct, no guarantee can be made as to the accuracy and completeness of any information within this website. The information and publications provided within this website are meant only to help educate the reader and are, in no way, intended to replace a physician's care or prescribed medication. Users are encouraged to independently verify any conclusions or information.

Putting the Pieces Together, Inc. is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.

Copyright ©2019 PPT Health

Sign Up for Our Health Newsletter!

Recieve Exclusive Promotions In Every Newsletter, including information related to:

  • Our disease protocols
  • Recommended nutrients and formulas
  • Living a healthy lifestyle, naturally


Note: We will not share your email address with any other party. If you wish to opt out of the newsletter distribution, you may unsubscribe at any time.